Successful treatment of vulvar lichen sclerosus with topical tacrolimus.

A 19-year-old woman was admitted to our department with a history of itching and pain of the vulvar region. During a period of 6 months, her clinical symptoms had significantly deteriorated resulting in painful urination and defecation in addition to dyspareunia. Clinical examination showed well-demarcated, smooth, whitish shiny plaques that affected the labia minora, introitus vaginae, and the clitoral hood. Lesions extended to the posterior fourchette, perineum, and anus. The mucosa appeared thin and fragile with a cellophane paper–like texture. The clinical picture suggested a diagnosis of lichen sclerosus.